Expanding knowledge and improving outcomes

We fund innovative research projects in the UK that expand knowledge, improve patient outcomes and pioneer new forms of orthopaedic treatment. Here are just a few of our recent research projects.


Analysing health data on MSK patients, particularly those with long-term knee problems, to find out the period of time from knee surgery to total joint replacement

Posted on: 30-04-2024

Using Machine Learning to detect and predict loosening of the femoral component of an uncemented total hip replacement

Posted on: 20-03-2024

Imaging the recovery of muscles following nerve trauma

Posted on: 09-02-2024
Dr Matthew Wilcox from UCL Centre for Nerve Engineering is a recipient of our Early Career Research Fellowship for his research into regenerative treatments for nerve injury and disease.

Evidence-based guidelines for the optimal design of rigid ankle-foot orthosis

Posted on: 26-01-2024
Computational models have been developed to measure the effect of material thickness and reinforcement design on stiffness of Ankle-Foot Orthosis (AFO) . This research project aims to translate this lab-based research into clinical practice.

An open-source finite element ankle model for in-silico assessment of ankle treatment

Posted on: 16-01-2024
Dr Elise Pegg, a Senior Lecturer at the University of Bath and recipient of an ORUK Early-career Research Fellowship, aims to create a fully open-source finite element ankle model, including bones, ligaments, and cartilages, appropriate musculoskeletal loading for a standardised representation of ankle biomechanics and pre-clinical ankle joint analysis.

Arthroplasty Research Cohort (ARC) Study -A collaborative, longitudinal observational cohort study of patients undergoing primary hip and knee replacements in the United Kingdom

Posted on: 03-01-2024
The team behind this research project aims to recruit a nationally representative cohort of patients receiving hip and knee replacements to track outcomes from procedures and facilitate clinical trials.

Establishing inhibition of MMP-14 as a viable therapeutic in Dupuytren’s Disease

Posted on: 13-12-2023
This three-year research study at the Davidson Lab at the University of East Anglia builds on earlier studies highlighting the importance of genetic variations called single nucleotide polymorphisms (SNPs), and in particular the enzyme Matrix Metalloproteinase 14 (MMP-14), in the incidence and progression of Dupuytren's Disease.

Studying outcomes in hip surgery using national datasets

Posted on: 04-12-2023
Revision hip replacement, which involves a partial or a complete exchange of the prosthesis that was implanted during the original (‘primary’) surgery, is a complex procure and success rates vary widely. In this research project, funded by ORUK in partnership with the British Hip Society, the researchers analysed data from the National Joint Registry from 2011-2020.

Defining the pro-nociceptive role of neutrophils in chronic widespread pain

Posted on: 06-11-2023
This research project, co-funded by ORUK, Barts Charity, Versus Arthritis UK, Royal Society and Cancer Research UK, is analysing pain mechanisms along the Neuroimmune axis and aiming to establish whether there might be a pro-nociceptive role for neutrophils in causing Fibromyalgia-like pain.