Our 3R principles

Using animals in research

We are dedicated to improving patient lives and outcomes through high quality research to better diagnose and treat MSK disorders. To achieve this, many types of research methods are harnessed to achieve results. These include clinical trials, use of tissues samples, computer models and, when appropriate, animals. All approaches, including research using animals, play a vital role in the medical research process.

As a proud member of the AMRC, we support the principle of using animals in research, when necessary, to advance diagnosis and treatment of serious health conditions, where there is no alternative that can be used.

We do not takes the decision to fund animal research lightly. We are committed to undertaking high quality animal research that is well-designed, uses rigorous and expert peer review, is well-reported, and ethically justified.

High standards of animal welfare – including housing conditions, well-trained animal technologists – are vital to us. These minimise discomfort for animals and enable researchers to get reliable results. We regularly adopt best practice and ensure we can exceed the regulatory requirements to improve animal welfare and science.

Our 3R principles

We are committed to the 3Rs of reduction, replacement and refinement, as basic principles of humane animal research. We actively employ these to improve animal welfare. Research funded outside of the UK must be carried out in the spirit of UK legislation as well as being compliant with all local legislation and ethical review processes.

We are committed to openness and transparency around the use of animals in research. We recognise that not everybody is comfortable with the use of animals in research. Along with other medical research charities, we work together through AMRC to continually review our funding practices and engage with the wider scientific community to encourage better practice and development of animal alternatives.