OBB-0010

Evaluation of targeted fluorescent dyes for assessing the tumour margin in a 3D cancer model


Step 1 of 5

Section 1 - Basic information about you and your application:



Title of research project
Evaluation of targeted fluorescent dyes for assessing the tumour margin in a 3D cancer model

Project summary

FGS in sarcoma surgery- fluorescence mapping to quantify fluorescence and correlate with pathological margins.

Type of project
Research

Type of research
Laboratory

Specialty/Area:
Osteosarcoma

Start date
12/02/2024

End date
19/07/2024

Section 2 - Purpose of the research and originality

Aims / Objectives:

The aim of this project will be for the student to attend FGS sarcoma surgery at Newcastle upon Tyne Hospitals in order to learn about the technique. The next objective will be to study the fluorescence images with the aim of applying a software application that will convert areas of fluorescence intensity into a heat map for quantification.

Background to investigation

The North of England Bone and Soft Tissue Tumour Service in Newcastle upon Tyne is the lead centre for a UK-wide randomised controlled trial of fluorescence guided surgery (FGS) called SarcoSIGHT. This trial is funded by the NIHR and aims to assess whether patients randomised to FGS for the resection of their sarcoma will have a lower positive margin rate compared to patients not receiving FGS. As part of the trial the surgeons performing FGS will take images of the sarcoma specimens which will be assessed in detail using a technique called fluorescence mapping to correlate this with the subsequent pathology results.



Purpose of the research and originality(Required)

Other documents

Applicant CV: Download here